September 2016 SPDS Book

Stakeholder Panel on Dietary Supplements Background and Fitness for Purpose for Vitamin K1 and K2

Inger Reidun F. Aukrust, PhD Kappa Bioscience AOAC meeting Dallas, TX 16.September 2016

Background on Vitamin K

“Vitamin K”, the generic name for a family of compounds with a common chemical structure of 2-methyl-1,4-naphtoquinon, is a fat-soluble vitamin. Two Primary groups: ▪ Vitamin K1 (phylloquinone, defined as the sum of cis and trans isomers) ▪ Vitamin K2 (the menaquinone series, MK4 through MK14). MK4 and MK7 are the most well-studied menaquinones. Defined as all- trans K2-MK4 and all- trans K2- MK7.

▪ MK7 is produced synthetically or via a fermentation process ▪ In fermented produced MK7 there will be small amount of MK6.