Centrifugation Application Notes
UPSTREAM
DOWNSTREAM
1st Inactivation (Formalin)
Embryonated Chick Eggs
Filtration
Inoculation
Concentration
Zonal Centrifugation
Incubation
Detergent Fragmentation
Candling
Centrifugation
Chilling Overnight
2nd Inactivation (Formalin)
UF Diafiltration
Harvest (Pool Allantoic Fluid)
Sterile Filtration
Clarification
Final Concentrate Product
Fig. 1. Typical workflow for egg-based influenza vaccine manufacturing. 1
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