Brain 17 Vienna



• The Making of the 2016 Update of the WHO brain tumor classification

The 2016 update of the WHO brain tumor classification

• Update on most important changes • Diffuse glioma • Embryonal tumors • Other newly introduced entities and variants

• Implications on neuropathological practice & molecular marker testing

Dr. Adelheid Wöhrer Institute of Neurology



The WHO brain tumor classification

Prior to 2016

• Brain tumor classification based on histogenesis • Microscopic similarities of tumors with different cells of origin • Based on hematoxylin and eosin-stained sections + immunohistochemical expression of lineage-associated proteins (+ ultrastructure)

Harvey Cushing

2016 update of the 4 th edition



In the meantime

2014 HaarlemMeeting, the Netherlands

• Large-scale studies revealed the genetic basis of tumorigenesis of adult and pediatric brain tumors • Molecular markers provide prognostic and/or predictive information within diagnostic categories • Canonical genetic alterations may be used to define specific entities

• Under the auspices of the International Society of Neuropathology

• Aim: Providing guidelines for how to incorporate molecular findings into brain tumor diagnostics • Set the stage for a major revision of the 2007 CNS WHO classification




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