Brain 17 Vienna
All presentations of the Multidisciplinary Management of Brain Tumours course in Vienna 2017, available for the participants.
07.11.2017
Outline
• The Making of the 2016 Update of the WHO brain tumor classification
The 2016 update of the WHO brain tumor classification
• Update on most important changes • Diffuse glioma • Embryonal tumors • Other newly introduced entities and variants
• Implications on neuropathological practice & molecular marker testing
Dr. Adelheid Wöhrer Institute of Neurology
1
2
The WHO brain tumor classification
Prior to 2016
• Brain tumor classification based on histogenesis • Microscopic similarities of tumors with different cells of origin • Based on hematoxylin and eosin-stained sections + immunohistochemical expression of lineage-associated proteins (+ ultrastructure)
Harvey Cushing
2016 update of the 4 th edition
3
4
In the meantime
2014 HaarlemMeeting, the Netherlands
• Large-scale studies revealed the genetic basis of tumorigenesis of adult and pediatric brain tumors • Molecular markers provide prognostic and/or predictive information within diagnostic categories • Canonical genetic alterations may be used to define specific entities
• Under the auspices of the International Society of Neuropathology
• Aim: Providing guidelines for how to incorporate molecular findings into brain tumor diagnostics • Set the stage for a major revision of the 2007 CNS WHO classification
5
6
1
Made with FlippingBook - Online catalogs