Brain 17 Vienna

non-small cell lung cancer brain metastases RTOG 0320

1 – 3 brain metastases

randomise

whole brain radiotherapy & SRS

Temozolomide

Erlotinib

control

Temozolomide

Erlotinib

not biomarker enriched

Additional systemic therapy in NSCLC brain metastases

Sperduto et al 2013, Int J Radiat Oncol Biol Phys, 85(5): 1312-8