Brain 17 Vienna

Medulloblastoma - Quality of Radiotherapy

Author/ study

Pat. ”low quality” ”high quality” Survival

Significance

RT 1983-89 n=41

Packer et al., 1991

108 RT 1975 -82 n=67

49% vs.82% 5-y PFS Significant P=0.004

Graben bauer et al., 1996 Miralbell, et al.1997

Significant p=0.02

40 RT before 1980 RT after 1980 5-y overall survival 64% versus 80%

41 adequate „helmet- technique“

5-y PFS 94 % versus 72 %

Significant p=0.016

77 36 inadequate „helmet- technique“ 169 Min. viol. :67 (40%) Maj. Viol. :53 (31%), Of these : 36 one maj. Viol.

49 (29%)

3 y. relapse rate 33% : all patients 23 % : corr. Treatment 17% : one maj. Viol. 67% : two maj. Viol. 78% : three maj. Viol.

Significant. P=0.04

Carrie et al., 1999

11 two maj. Viol. 6 three maj.Viol.

Not signif. P=0.42

Packer et al., 1999

63 Violations : 20

No viol.: 43 5-y PFS

81% vs. 70%