Brain 17 Vienna

Radiobiology of RT/SRS/FSRT

• The goal of any medical intervention is to reach the highest role of clinical success in terms of desired effect with the minimum rate of side effects treatment related • Historically radiation was delivered considering a variable safety margin to include microscopic tumor infiltration in normal tissue • The relationship between time of radiation, dose and number of fractions, to influence the biological effect is based on 4Rs of ionizing radiation

A. Santacroce, et al., biomed research International, 2013