Brain 17 Vienna

Neural Stem Cells and RT toxicity

- NSCs exhibit exquisite in situ radiosensitivity

- Radiation can directly depopulate NSC niches, causing immediate loss of NSC- mediated repair and plasticity - Indirect effects of radiation are inflammatory in nature, dose dependent, and capable of stunting neurogenesis even at low doses - The scope of NSC dysfunction is age dependent, with greater effects noted in immature brains

Barani I, IJROBP 2007