Brain 17 Vienna

Conclusions

 Improvement of radiotherapy safety, with promising efficacy in patients with brain metastases  Well defined dose constraints (QUANTEC, ESTRO, RTOG)  New knowledge concerning the role of Neural Stem Cells permitted to identify brain regions involved in plasticity and repair processes (Hippocampus e.g.)  Randomized controlled trials have demonstrated significant activity of Memantine and Donepezil for neurocognitive impairment prevention, in patients treated with cranial radiotherapy for primary and metastatic brain tumors  Even with new treatments (BEV e.g.) radiation necrosis remains a challenge; better treatment for that is prevention