Brain 17 Vienna

Chemotherapy and the BBB

Drug

CSF penetration

Nitrosoureas (ACNU,BCNU; CCNU, Fotemustine)

++

Procarbazine

++

Thiotepa

+

Dacarbazine Temozolomide

(+) ++ +/- ++ -/+ - ++ -/+ -/+

Cyclophosphamide, Ifosfamide

AraC

Methotrexate

5-FU

(++)

Anthracyclins Liposomal doxorubicine

VM26

Etoposide

Vincaalkaloids, Taxanes

-

Topotecan

++

Cisplatin, Carboplatin

-

Müller et al., Malignant brain tumors 1995