Brain 17 Vienna

Temozolomide

• Imidazotetrazine derivative of dacarbazine • Conversion in the systemic circulation at physiological pH to the active compound, 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC) • Good BBB penetration • Oral application (note: there is also an i.v. formulation) • Methylation of O6 guanine:

Tumor cell death

03/01/13