Brain 17 Vienna

Inactivation of MGMT gene by promoter methylation

unmethylated MGMT promotor

Chemo- resistance

Transcription/translation

MGMT gene

MGMT promoter

active

„Non-Responder“

MGMT promotor methylation

Chemosen- sitivity

Transcription/translation

MGMT gene

CH 3 CH 3 MGMT promoter CH 3 CH 3 CH 3

inactive

„Responder“