ESTRO 2020 Abstract book

S465 ESTRO 2020

During the last control, 33% of patients reported complete pain relief, 27% relief larger than 50% and 8.5% relief lower than 50%. HSS: The first analysis was conducted in 2006 and comprised 623 heel spurs irradiated using X-rays (97%), 60 Co gamma beams, electrons and high energy photons with a fraction dose of 1-3 Gy to a total dose of 1- 45 Gy. After treatment 48% of the patients reported a lack of pain, 21% reported pain relief greater than 50% and 17% reported pain relief less than 50%. The mean of pain relief duration was 72 months. The second analysis (mean of FU 60 months) comprised 55 patients irradiated between 2013-2016 with 6 MV photons using 1 Gy fd to a TD of 6 Gy. 64 % of them reported pain relief at the end of RT (50% pain reduction). Duration of pain relief was in the range of 10 to 64 months. EPH: The first analysis was performed in 2015 and comprised 50 cases (mean FU 15.2 months) treated using 6 MV photons with 1 Gy fd to a TD of 6 Gy. The mean of pain relief was 70.2% one year after the treatment. As yet we have the very preliminary data from the second analysis – the data collecting and analysis is ongoing. Treated group comprised 37 patients (median of symptoms duration 13 months) treated with 6 MV photons using the fraction dose of 1 Gy up to TD of 6 Gy. During the first control the complete pain relief reported 42% of patients, larger than 50% and smaller than 50%, 25% and 8% respectively. Conclusions: The obtained results permit us to form the conclusion that radiotherapy of painful inflammatory diseases is a very safe (no adverse effects observed) and very effective treatment modality, and considering its simplicity (simple technique) and low cost, should be more commonly taken into account. Comparing older and actual results, we do not see any positive impact of modern radiotherapy equipment on the treatment results; contrarily – the results seem to be worse. SP-0764 (Re-)Irradiation in Morbus Dupuytren and Ledderhose R. Steenbakkers 1 1 UMCG University Medical Center Groningen, Radiation Oncology, Groningen, The Netherlands Abstract text Dupuytren’s disease (DD) and Ledderhose disease (LD) are both a fibroproliferative condition of the hand and feet, respectively. DD or palmar fibromatosis is quite common disease and the prevalence is estimated to be 1-6%, especially at older age in northern Europe. Eventually, DD results into a progressive digital flexion contracture, mainly involving the little finger and ring finger, which hampers the function the hand. LD of plantar fibromatosis is a uncommon disease. The prevalence is not really known, but estimated to be less than 0.1 %. LD appears as one or more subcutaneous painless nodules which grow slowly and might become symptomatic (painful) during walking or in standing position and are sometimes very disabling when they increase in size. Treatment for DD, invasive strategies are injections of collagenase clostridium histolyticum, needle fasciotomy and extended surgical intervention. Most common non- invasive treatment is radiotherapy, which results into regression of symptoms or lack of progression. Invasive treatment for LD is not recommended. Currently, only radiotherapy seems to be beneficial for LD, resulting into regression of symptoms. Long-term side-effects using radiotherapy for DD and LD are uncommon. Skin dryness is observed in 25% of the treated patient. Radiotherapy induced malignancies have

Symposium: Current status of radiotherapy for non- malignant disease outside the brain

SP-0762 Stereotactic ablative radiotherapy for refractory ventricular tachycardia R. Jumeau 1,2 1 centre Hospitalier Universitaire Vaudois, Department Of Radiation Oncology, Lausanne, Switzerland ; 2 riviera- Chablais Hospital, Radiation Oncology Unit, Rennaz, Switzerland Abstract text Ventricular tachycardia (VT), an important cause of mortality and morbidity, commonly occurs in the context of structural heart diseases. Antiarrhythmic drug therapy (AAD) and catheter ablation are the cornerstone of VT management, but both treatments have limited efficacy and potential adverse effects. Additionally, despite significant progress in catheter ablation efficacy, the recurrence rate after a first VT ablation is about 50%, exposing patients to multiple CA procedures and implantable cardioverter-defibrillator shocks. Stereotactic body radiotherapy (SBRT) is routinely used in oncology to treat non-invasively solid tumors with high precision and efficacy. Recently, this technology has been evaluated for the treatment of VT. This lecture will present the basic underlying principles, proof of concept and main results of trials and case series that used SBRT for the treatment of VT refractory to AAD and catheter ablation. SP-0763 The role of radiotherapy in the management of painful inflammatory diseases L. Miszczyk 1 , L. Tomasz 1 , M. Miszczyk 2 1 maria Sklodowska-Curie Memorial Cancer Center And Institute Of Oncology, Radiotherapy, Gliwice, Poland ; 2 maria Sklodowska-Curie Memorial Cancer Center And Institute Of Oncology, 3rd Radiochemotherapy Ward, Gliwice, Poland Abstract text Introduction: There is a wide selection of painful inflammatory diseases treated with irradiation. Even in our institution we deal with seven of them: PHS (periarthritis humeroscapularis), EPH (epicondylitis humeri), HSS (heel spur syndrome), Achilles tendonitis and rarely with gonharthritis, painful chronic ostitis and painful osteoporotic fractures of vertebras. Due to the limited presentation time, I will focus only on the first three mentioned. Purpose: An evaluation of the effectiveness of PHS, EPH and HSS radiotherapy. Material and method: After a long period of limited interest in this kind of treatment, in the late nineties in Gliwice we launched it again, hence we have 20 years long experience with this form of radiotherapy. In this presentation I would like to show and compare two sets of results for each disease – older and actual (now, ongoing – incomplete analysis). In all the cases, the patients were irradiated using two opposite fields using a 2D technique. Results: PHS: The first analysis was completed in 2004 and compared 30 cases with a mean FU of 18 months. All were irradiated using 60 Co gamma beams with 1 Gy fd to TD of 6 Gy. The mean of pain relief was 93% one year after the treatment. The second analysis comprised 119 cases irradiated with 6 MV photons using 1 Gy fd to TD of 6 Gy. The mean of pain relief was 27% 1 month after the treatment and 53-83% in the time of the next controls.