ESTRO 2020 Abstract book

S474 ESTRO 2020

On univariate analysis, lower sexual satisfaction scores were associated with female sex (p=0.04), higher medical comorbidity (p=0.008), fewer years from treatment completion (p=0.006) and self-reported change in sexual function or relationship (p<0.001). Sexual satisfaction scores were not significantly associated with QLQ-C30 global health or functional scale scores, age, relationship status, knowledge of HPV status, PROMIS anxiety or depression scores or toxicity (xerostomia, dysphagia, voice, taste or the MDASI symptom severity score). The majority reported no change in their overall relationship (62/109; 57%) compared with pre-diagnosis, while 29/109 (27%) and 16/109 (15%) reported a positive and negative change, respectively. When asked about changes in their sexual relationship, half reported no change (57/107; 50%), while a third reported a negative change (40/107;37%). The majority reported stable sexual function compared to before treatment (65%), while few (28%) reported a negative change. Seven patients reported separating from their partner between treatment and enrollment.

Conclusion With all limitations of a single-center retrospective analysis, our data suggest that single-fraction e-BT is highly effective, with a very low toxicity profile and a shorter overall treatment time compared to other modalities. PO-0791 Sexual health in HPV-related oropharyngeal cancer survivors after (chemo)radiotherapy G. Casswell 1 , K. Gough 2 , A. Drowdowsky 2 , M. Bressel 3 , S. Shrestha 1 , A. Coleman 1 , D. Rischin 4 , I. D'Costa 1 , T. Fua 1 , A. Tiong 1 , C. Liu 1 , B. Solomon 4 , L. McDowell 1 1 Peter MacCallum Cancer Centre, Department of Radiation Oncology, Melbourne, Australia ; 2 Peter MacCallum Cancer Centre, Department of Cancer Experiences Research, Melbourne, Australia ; 3 Peter MacCallum Cancer Centre, Centre of Biostatistics and Clinical Trianls BaCT, Melbourne, Australia ; 4 Peter MacCallum Cancer Centre, Department of Medical Oncology, Melbourne, Australia Purpose or Objective To characterise long-term sexual health and relationship changes in HPV associated oropharyngeal cancer (HPV- OPC) survivors treated with (chemo)radiotherapy (CRT/RT). Material and Methods We undertook a cross-sectional study in HPV-OPC survivors ≥12 months following radical CRT/RT. Eligible patients completed the EORTC Quality of Life Questionnaire Core 30 (QLQ-C30) and Sexual Health Questionnaire (QLQ- SHQ22), MDASI-HN, PROMIS Anxiety-Short Form 7a and Depression-Short Form 8b, and a customised relationship status questionnaire. Results 136 patients were enrolled from November 2018 to May 2019. Median age was 61 years (range 42-87) and 84% were male, 72% currently partnered (married/de facto), 99% heterosexual, 83% current non-smokers, and 67% regular alcohol consumers. Only 52% reported knowing their cancer was caused by HPV. Patients were stage II (2%), III (15%), IVa (74%) and IVb (10%) by AJCC7 staging. Most patients received 70Gy/35# (96%) with concurrent chemotherapy (88%). The median time from RT/CRT completion to enrolment was 2.8 years (range 1.0-5.5). Descriptive statistics for QLQ-SHQ22 scales and items are presented in Table 1. Most patients (71/131; 60%) reported an active sex life as important (‘Quite a bit’ or ‘Very much’), however, only 20% (26/133) reported significant sexual activity (‘Quite a bit’ or ‘Very much’) in the last four weeks. Few patients (19%) reported that treatment had significantly impacted their sexual activity (‘Quite a bit’ or ‘Very much’).

Conclusion Sexual function is important to HPV OPC survivors. Sexual satisfaction was associated with a number of non- modifiable variables including sex, medical comorbidity and time since completing CRT/RT. The majority of patients reported no change in their relationship from prior to their cancer diagnosis; the majority of the remainder reported a positive change. PO-0792 Reproducibility of the Mixing Ability Test in patients with head and neck cancer J. Vermaire 1 , F.M. Weinberg 2 , C.P.J. Raaijmakers 1 , I.M. Verdonck-de Leeuw 3 , C.H.J. Terhaard 1 , C.M. Speksnijder 4 1 University Medical Center Utrecht, Radiation Oncology, Utrecht, The Netherlands ; 2 University Medical Center Utrecht, Oral and Maxillofacial Surgery and Special Dental Care, Utrecht, The Netherlands ; 3 VU University Medical Center, Otolaryngology-Head and Neck Surgery, Amsterdam, The Netherlands ; 4 University Medical Center Utrecht, Oral and Maxillofacial Surgery and Special Dental Care & Julius Center for Health Sciences and Primary Care & Head and Neck Surgical Oncology, Utrecht, The Netherlands Purpose or Objective Mastication is a learned automatic complex process involving interaction of hard and soft tissues in order to grind a food bolus prior to swallowing. It involves several nerves, muscles, and connective tissue structures, such as