Quantitative Methods 2017

Evidence-based medicine David Lawrence Sackett

• Evidence based medicine not synonymise with RCT • Two examples: – The accuracy and precision of diagnostic tests – The power of prognostic markers and prediction models Can we use multivariable NTCP-models for evidence-based selection of patients for and clinical validation of new radiation technologies aiming at reduction of side effects?

Sackett et al , BMJ 1996