Quantitative Methods 2017

Model-based approach 4 steps STEP 1: NTCP model – Multivariable NTCP-models STEP 2: Individual dose comparison – Dose reduction ( D Dose ): relevant DVH parameters? STEP 3: Estimate NTCP reduction (ΔNTCP) – Translate D Dose to D NTCP STEP 4: Validation – External validation NTCP-model with new technology Development Validation

Langendijk, et al. Radiother Oncol 2013