Expert Review Panel for Dietary Supplements

4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method? 6. Based on the supporting information, what are the cons/weaknesses of the method?

Method may add some clarifications about the procedure guideles in preparation of LCS and MRL samples. They may also calify how the selection of the materials is made about the samples to meet scope of the method.

The method is straight forward and uses advance technology available at this time.

The authors have not proved uniqueness/specificty of target peptided selected for the idenitification of the respective proteins.

7. Any general comments about the method?

The method is suitable for the pupose

Recommendation for the Method

V. Final Recommendation Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

The methods meets most of the criteria of SMPR. The authors may complete the gaps metioned (fals positive determination at target conc. of 10% and also with non-target peptdes and proetisn). The method may be moved to First Action status.