Expert Review Panel for Dietary Supplements

II. Review of the Method Only 1. Does the applicability of the method support the applicability of the SMPR? If not, please explain what is missing. 2. Does the analytical technique(s) used in the method meet the SMPR? If not, please specify how it differs from what is stated in the SMPR. 3. Are the definitions specified in the SMPR used and applied appropriately in the method? If no, please indicate how the terms are used. 4. Does the method, as written, contain all appropriate precautions and warnings related to the method's reagents, components, instrumentation, or method steps that may be hazardous? If no, please suggest wording or option(s). III. Review of Supporting Information 1. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference.

Partially. Some of the compounds listed in Table 2 of the SMPR were not addressed.

Partially. Depending on interpretation the method submitted may not meet the required number of replicates stated for SLV matrix study under the POI at low concentration section. However all of the POI data presented does meet the SMPR requirements at the relevant levels.

Yes.

No reagent hazards noted. Given that some are mildly hazardous it would likely be helpful to maybe recommend analysts to read over the relevant MSDS as appropriate.

III. Review of Information in Support of the Method

Yes.