BCRB 2018

19/09/2018

Exponential and non-exponential growth

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Definitions

• Tumor volume doubling time (VDT): time required for tumor to double its volume • Growth fraction (GF): cells in the compartment of actively dividing cells • Cell-cycle time (Tc): time required to complete the cell cycle • Ts: duration of S-phase • Potential doubling time (Tpot): cell doubling time without any cell loss (Tpot = Tc/GF) • Cell loss factor (CLF): tumor cell loss during growth (CLF = 1 – Tpot/VDT)

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