BCRB 2018

Take home message II

Late effects: •

all tissues

•

complex pathogenesis (parenchyma, fibroblasts, endothelium, macrophages)

• • • •

irreversible (?)

dose-dependent latency

dose-dependent progression rate incidence (tolerance) ~ follow up

ESTRO BCR Course / Pathogenesis of NT effects – W. Dörr