BCRB 2018

α/β = int

/slope

1 /D

d

0.01 0.02 0.03 0.04 0.05 0.06 0.07 Reciprocal total dose (Gy –1 )

16.5

.0606

10.95

.0457 7.35 .0340 4.88 .0256 3.14 .0199 1.90 .0164 1.08 .0144

1 /D

α/E

α/β

–5

0

5

10

15

20

d

Dose per fraction (Gy)

Damage from a single fraction = αd + βd 2 Total damage from n fractions, E = n ( αd + βd 2 )

E = αD + βd D

E/D = α + βd

1 /D = ( α/E) + ( β/E)d

Michael Joiner

Basic Clinical Radiobiology 2018

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