BCRB 2018

Table 10.1: α/β values for human normal tissues and tumors Tissue/organ Endpoint α/β (Gy) 95% CL (Gy) Source Early reactions Skin Erythema 8.8 6.9; 11.6 Turesson and Thames (1989) Erythema 12.3 1.8; 22.8 Bentzen et al. (1988) Dry desquamation ~ 8 N/A Chogule and Supe (1993) Desquamation 11.2 8.5; 17.6 Turesson and Thames (1989) Oral mucosa Mucositis 9.3 5.8; 17.9 Denham et al. (1995) Mucositis 15 –15; 45 Rezvani et al. (1991) Mucositis ~ 8 N/A Chogule and Supe (1993)

Telangiectasia Telangiectasia Telangiectasia Telangiectasia Mean Late 2.9 Mean Early 10.6 H&N, Lung tumors high , Breast, Prostate tumors low 2.8 2.6 2.8 3.8 1.7 3.5 4.0 4.7 3.5 1.7; 3.8 2.2; 3.3 –0.1; 8.1 1.8; 5.7 0.6; 2.6 0.7; 6.4 2.3; 5.6 2.4; 7.0 0.7; 6.2 Fibrosis Cosmetic change in appearance Induration (fibrosis) Breast Oedema Impaired shoulder movement Brachial plexopathy Brachial plexopathy Optic neuropathy <3.5 N/A N/A ~ 2 1.6 –7; 10 Myelopathy Corneal injury <3.3 N/A Stricture/perforation Various late effects Pneumonitis

Late reactions Skin/vasculature

Turesson and Thames (1989) Bentzen et al. (1990) Bentzen and Overgaard (1991) Haviland et al. (2013) Bentzen and Overgaard (1991)

Subcutis Breast

Haviland et al. (2013) Haviland et al. (2013) Haviland et al. (2013) Bentzen et al. (1989) Olsen et al. (1990) Powell et al. (1990) Jiang et al. (1994) Dische et al. (1981) Jiang et al. (1994) Deore et al. (1993) Dische et al. (1999) Bentzen et al. (2000) Dubray et al. (1995) Rezvani et al. (1991)

Muscle/vasculature/cartilage

Nerve

Spinal cord

Eye Bowel

2.9 3.9 4.3 4.0 3.1 3.5 4.0 3.8 0.8

–4; 10 2.5; 5.3 2.2; 9.6 2.2; 5.8 –0.2; 8.5 1.1; 5.9 3.3; 5.0 0.8; 14 –0.6; 2.5 6.5; 29 4.9; 24 ‘ Wide ’ 2.9; ∞ 3.6; ∞ –11; 43 7.0; 9.4 4.5; 11.3 1.6; 3.8 1.2; 5.7 1.5; 17 –1.1; 2.5 –1.4; 5.4

Lung

Lung fibrosis (radiological) Various late effects Various late effects Various late effects Various late effects

Head and neck

Stuschke and Thames (1999) Maciejewski et al. (1986) Maciejewski et al. (1990)

Supraglottic larynx Oral cavity + oropharynx

Tumours Head and neck Various

10.5 14.5 ~ 13 6.6 7.2

Stuschke and Thames (1999) Rezvani et al. (1993) Robertson et al. (1993) Maciejewski et al. (1989) Maciejewski et al. (1989)

Larynx

Vocal cord Buccal mucosa

Tonsil

Nasopharynx

16 8.2 8.5 2.7 3.5 4.9 0.6 0.4

Lee et al. (1995)

Lung (NSCLC, early)

Studchke and Pöttgen (2010)

Skin

Trott et al. (1984)

Prostate Breast

Vogelius and Bentzen (2018) Haviland et al. (2013) Geh et al. (2006) Bentzen et al. (1989) Thames and Suit (1986)

Oesophagus Melanoma Liposarcoma

Michael Joiner

Basic Clinical Radiobiology 2018

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