BCRB 2018

HR versus NHEJ

• NHEJ

• HR

– Repairs most DSB - 80% – Very important for radiosensitivity – Error prone

– Repairs fewer DSB – 20% – Important for radiosensitivity – Error free – S and G2 phase – responsible for change in sensitivity in the cell cycle – Varies more between cell lines (high in stem cells) – Defects common in cancer

– All parts of the cell cycle – Similar in all cell types