BCRB 2018

Repopulation: Mechanisms

vascular effects,

stem cell depletion

tissue hypoplasia

inflammation, macrophages

EGF-R ICAM-1

?!?

stem cells asymmetry loss

sterilised cells abortive divisions

stem cells acceleration

TGF-a (early) EGF (late) KGF

EGF KGF

compensation of cell loss

dose compensation

ESTRO BCR Course / NT overall treatment time – W. Dörr