BCRB 2018

19/09/2018

Targeting the hallmarks of cancer

• High specificity • Low toxicity (different from RT) • Interaction with RT • Radiosensitivity • Hypoxia • Proliferation • Immune activation • High therapeutic index • Target driven • Synthetic lethality • Contextual lethality

Hanahan & Weinberg Cell 2011

3

Framework

Target driven lethality (Oncogene addiction)

Synthetic lethality

Contextual synthetic lethality

4

Kaelin Nat Rev 2005

2