Vetoryl brochure 2019

Monitor

The Vetoryl dose should be titrated according to individual response as determined by monitoring of clinical signs and laboratory test results. Assessment should be performed pre-treatment and then at 10 days, 4 weeks, 12 weeks, and thereafter every 3 months, following initial diagnosis and after each dose adjustment. A positive response to Vetoryl therapy is regarded as an improvement in clinical signs and a Pre-Vetoryl Cortisol concentration of between 40 and 138 nmol/l. For detailed information on monitoring dogs treated with Vetoryl and guidance on dose changes, please refer to the monitoring and treatment flowchart. Efficacy of Vetoryl treatment According to vets who have treated a number of cases of hyperadrenocorticism, owners soon notice the difference and comment on the changes in their pet ix . Improvement of clinical signs such as polydipsia, polyuria, polyphagia, panting and lethargy occurs shortly after the start of treatment. Skin, coat and muscle changes take longer to reverse (usually 3-6 months).

Did you know that: • Vetoryl should be administered with food as this enhances the absorption of trilostane? • Monitoring is important because patients may need lower doses of Vetoryl after they have been on treatment for a period of time? • Pre-Vetoryl cortisol is superior in detecting an overdose and shows better correlation with the clinical signs than the results of the ACTH stimulation test? • Hypoadrenocorticism (‘Addisonian crisis’) is a known adverse reaction? For more information visit www.dechra.co.uk/prevetorylcortisol