ClearLLab 10C Case Book

M2 Cell Tube

Figure 17. This CD38 vs CD34 dot plot shows all viable cells. CD38 is uniformly expressed on lineage committed early progenitors having variable CD34. The aberrant population (purple) is positive for CD34 and express CD38 at lower and more variable level than that seen on normal immature B cells.

Figure 18. This HLA-DR vs CD34 plot shows all viable cells. HLA-DR is expressed on B cells, monocytes (green), plasmacytoid dendritic cells and CD34 positive progenitors. CD34 is expressed on early progenitors. The aberrant population (purple) is positive for CD34 and HLA-DR.

Figure 19. This CD19 vs CD123 dot plot shows all viable cells. CD19 is expressed by B cells. CD123 is expressed by basophils, plasmacytoid dendritic cells, monocytes (green) and CD34 positive progenitors. CD19 positive B cells (red) normally do not express significant CD123. The aberrant population (purple) is positive for CD19 and CD123.

Figure 20. This CD19 vs CD34 dot plot shows all viable cells. CD19 is expressed by B cells. CD34 is expressed on early progenitors. Mature CD19 positive B cells (red) do not express CD34. The aberrant population (purple) is positive for CD19 and CD34. The small population of CD34 positive and CD19 negative cells (top left) are normal myeloid progenitors.

Table of Contents > Neoplastic Process of B-cell Origin > Case#5:BAcuteLymphoblastic Leukemia/LymphoblasticLymphoma

Every Event Matters

127 Beckman Coulter • ClearLLab 10C Panels • C30134 AA