AOAC SPIFAN Stakeholder Program Meeting Book (March 17, 2021)

Analytical Methods

Detection

• CAD use same nebulization principle as ELSD, but charge transfer makes detector more sensitive, and typically less linearity problems than ELSD • UV detectors are sensitive but limited to 190–210 nm with response for saturated phospholipids lower than UV response than unsaturated phospholipids

Analytical Methods

31 P NMR

• Highly selective, accurate, less prone to interferences • Does not require clean-up or chromatographic separation, although sample concentration often required • Major disadvantage is equipment specialised and expensive

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