Hematological Malignancies

AETHERA PFS per Investigator

HR = 0.50 [95% CI (0.36, 0.70)] Median BV = NE (–, –); Placebo = 15.8m (8.5, –) 24-month PFS rate BV = 65%; Placebo = 45%

10 20 30 40 50 60 70 80 90 100

Stratified Hazard Ratio

N Events (Months) Median 164 89 15.8 165 60 --

Percent of Subjects Free of PD or Death 0 Placebo+BSC BV+BSC

0.50

0

4

8

12

16 20

24 28

32

36 40

44 48

52

Time (Months)

N at Risk (Events) Pla+BSC BV+BSC

164 (0) 113 (48) 92 (67) 83 (76)

77 (81) 71 (85)

61 (88) 45 (89)

28 (89) 40 (59)

23 (89) 13 (89) 33 (60) 16 (60)

3 (89) 4 (60)

3 (89) 3 (60)

0 (89) 0 (60)

165 (0) 149 (12) 133 (27) 122 (36) 111 (45) 103 (52) 90 (55) 62 (58)