ESTRO PT 2018

Physico-chemical factors

Glutathione

Tripeptide containing a sulfhydryl group (-SH): gamma-Glu-Cys-Gly

Cys

Gly

  Glu

+

O

H

O

NH

O

O

3

C-C-CH-CH-C-N-C-C-N-CH-C

2

2 2

- O

O -

H

H

CH

H

2

SH

acts as an oxidative buffer : key role in detoxification by interacting with hydrogen and organic peroxides

2 GSH + R-O-OH GSSG + H O + ROH 2

Damage avoidance !