ESTRO PT 2018

Physics meets biology

Local Microscopic Dose Distribution

X-rays

Carbon Ions

Density of ionization in particle tracks is described

Linear Energy Transfer (LET)

Definition: average energy deposition (keV) per traversed distance (1 µm)

Cell nucleus

low-LET

high-LET

< 20 keV/µm

> 20 keV/µm

„Randomized DNA damage“

„Clustered DNA damage“

10 m m

Krämer & Kraft 1994