ESTRO PT 2018

Effect of Ionizing radiation on biomolecules

direct effect

damage

interaction of photons or electrons with DNA

targeted effects

O + + e -

H

H

O

e -

2

2

The maximum amount of radiation-induced genetic damage is formed shortly (minutes to hours) after radiation exposure

p +

OH - + H

3 O + + e - aqu.

damage

indirect effect