ESTRO PT 2018

DNA repair: Non-homologeous endjoining (NHEJ)

Double Strand Break (DBS)

poly (ADP-ribosylation)

PARP recognizes both single and double strand breaks. PARP causes poly (ADP- ribosylation) to enhance access to DNA single strand repair proteins such as XRCCI, Ligase III and DNA polymerase .

PARP

Ligase

XRCC

DNA-pol