ESTRO PT 2018

Why do mammalian genomes tolerate error-prone repair ?

Satellite DNA in the region of centromers and telomers

Coding genes separated by repetitive DNA elements (~ 1.5%)

(SINE and LINE): Short and long interspersed repetitive elements, consisting of introns and regulatory sequences (~ 24%) , repetitive DNA (~ 59%) and non- coding DNA (~ 15%)

because > 98% of the DNA sequence is non-coding !