paediatrics Brussels 17

Posterior Fossa Syndrome

• Occurs in approx. 15-25% of midline medulloblastomas • Onset usually within 12-24 hrs of surgery • Slowly improves, but significant long term morbidity • Results from surgical damage to the efferent cerebellar pathways • Correlated with hypertrophic olivary degeneration (inferior olivary nuclei) • ? Damage to dentate nuclei/superior cerebellar peduncles • May see decreased CBF in frontal lobes