paediatrics Brussels 17

Treatment of Posterior Fossa Ependymoma Subgroups

Table A8. Multivariable Cox Proportional Hazards Model of 10-Year Survival in EPN_PFA

PFS

OS

P

P

Variable

HR (95% CI)

HR (95% CI)

All cohorts (PFS, n = 645; OS, n = 646) Age

0.98 (0.96 to 1.00) 1.74 (1.39 to 2.18) 0.65 (0.50 to 0.83) 1.03 (0.80 to 1.34) 1.31 (1.05 to 1.63) 0.95 (0.92 to 0.99) 1.74 (1.21 to 2.52) 0.31 (0.21 to 0.45) 1.03 (0.70 to 1.51) 1.09 (0.78 to 1.53) 1.00 (0.96 to 1.40) 1.91 (0.98 to 3.75) 0.84 (0.47 to 1.48) 0.82 (0.42 to 1.61) 1.46 (0.82 to 2.59) 1.01 (0.90 to 1.12) 2.77 (1.43 to 5.38) 2.59 (1.31 to 5.10) 0.99 (0.96 to 1.03) 1.84 (1.28 to 2.66) 1.10 (0.72 to 1.67) 1.00 (0.65 to 1.54) 1.19 (0.81 to 1.77)

.07

0.99 (0.96 to 1.01) 2.05 (1.52 to 2.76) 0.52 (0.38 to 0.72) 0.89 (0.63 to 1.26) 1.39 (1.04 to 1.85) 2.26 (1.46 to 3.49) 0.28 (0.18 to 0.45) 0.78 (0.49 to 1.25) 1.17 (0.77 to 1.78) 1.01 (0.97 to 1.06) 1.80 (0.83 to 3.88) 0.61 (0.31 to 1.18) 0.77 (0.35 to 1.67) 2.51 (1.18 to 5.33) 1.04 (0.91 to 1.19) 3.26 (1.49 to 7.12) 2.86 (1.21 to 6.77) 1.01 (0.96 to 1.06) 1.84 (1.08 to 3.12) 1.02 (0.56 to 1.85) 1.42 (0.73 to 2.78) 0.89 (0.51 to 1.53) 0.96 (0.91 to 1)

.26

Incomplete resection Adjuvant radiation Adjuvant chemotherapy

, .001 , .001

, .001 , .001

.80 .02

.51 .02

Male

GENE cohort (PFS, n = 258; OS, n = 259) Age

.008 .003

.03

Incomplete resection Adjuvant radiation Adjuvant chemotherapy

, .001 , .001

, .001

.88 .62

.30 .46

Male

CERN cohort (PFS, n = 86; OS, n = 86) Age

.92 .06 .54 .57 .20

.53 .13 .14 .50 .02

Incomplete resection Adjuvant radiation Adjuvant chemotherapy

Male

St Jude ’ s RT1 Cohort (PFS, n = 104; OS, n = 104) Age

.9

.61

Incomplete resection

.003 .006

.003

Male

.02

Burdenko cohort (PFS, n = 197; OS, n = 197) Age

.80

.70 .02 .94 .30 .66

Incomplete resection Adjuvant radiation Adjuvant chemotherapy

.001

.66 .99 .38

Male

Abbreviations: CERN, Collaborative Ependymoma Research Network; GENE, Global Ependymoma Network of Excellence; HR, hazard ratio; OS, overall survival; PFS, progression-free survival.

Table A9. Multivariable Cox Proportional Hazards Model of Survival in EPN_PFB in All Cohorts

Progression-Free Survival (n = 132)

Overall Survival (n = 132)

P

P

Variable

HR (95% CI)

HR (95% CI)

Age

0.99 (0.97 to 1.02) 3.93 (1.78 to 8.68) 0.49 (0.21 to 1.14) 1.64 (0.45 to 5.92) 0.76 (0.37 to 1.59)

.70

0.98 (0.92 to 1.04)

.45 .03 .48 .18 .74

Incomplete resection Adjuvant radiation Adjuvant chemotherapy

, .001

11.32 (1.28 to 100.41) 0.53 (0.09 to 3.06) 5.37 (0.45 to 64.12) 0.76 (0.15 to 3.79)

.10 .45 .47

Male

Abbreviation: HR, hazard ratio.

Table A10. Multivariable Cox Proportional Hazards Model of 10-Year Survival in EPN_PFB in All Cohorts

Progression Free Survival (n = 132)

Overall Survival (n = 132)

P

P

Variable

HR (95% CI)

HR (95% CI)

Age

0.99 (0.96 to 1.02) 4.30 (1.89 to 9.77) 0.49 (0.21 to 1.16) 1.51 (0.42 to 5.41) 0.69 (0.32 to 1.47)

.52

0.97 (0.91 to 1.04) 11.06 (1.24 to 98.32) 0.51 (0.09 to 2.99) 4.93 (0.42 to 58.18) 0.77 (0.15 to 3.84)

.38 .03 .45 .20 .75

Incomplete resection Adjuvant radiation Adjuvant chemotherapy

, .001

.10 .45 .33

Male

Abbreviation: HR, hazard ratio.

© 2016 by American Society of Clinical Oncology

www.jco.org

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