paediatrics Brussels 17

RadiationOncology International Journal of biology physics

www.redjournal.org

Clinical Investigation

Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy Hugo Caˆmara-Costa, PhD, * Anika Resch, MSc, y Virginie Kieffer, MSc, z Cle´mence Lalande, MSc, x Geraldina Poggi, MD, k Colin Kennedy, MBBS, MD, { Kim Bull, PhD, { Gabriele Calaminus, MD, # Jacques Grill, MD, PhD, x Franc¸ois Doz, MD, ** Stefan Rutkowski, MD, y Maura Massimino, MD, yy Rolf-Dieter Kortmann, MD, zz Birgitta Lannering, MD, xx Georges Dellatolas, MD, PhD, * and Mathilde Chevignard, MD, PhD kk , on behalf of the Quality of Survival Working Group of the Brain Tumour Group of SIOP-Europe *National Institute of Health and Medical Research, INSERM U1178, Paris, France; y University Medical Center Hamburg-Eppendorf, Hamburg, Germany; z Saint Maurice Hospitals, Saint Maurice, France; x Institut Gustave Roussy, Villejuif, France; k Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy; { University of Southampton, Faculty of Medicine, Southampton, United Kingdom; # Paediatric Oncology, University of Muenster, Muenster, Germany; **Institut Curie and University Paris Descartes, Sorbonne Paris Cite´, Paris, France; yy Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy; zz Department of Radiation Therapy, University of Leipzig, Leipzig, Germany; xx Paediatric Oncology, University of Gothenburg, Gothenburg, Sweden; and kk Rehabilitation Department for Children With Acquired Neurological Injury, Saint Maurice Hospitals, Saint Maurice, and Sorbonne Universite´s, UPMC Universite´s Paris, INSERM CNRS, Paris, France

Received Feb 11, 2015, and in revised form Apr 4, 2015. Accepted for publication Apr 10, 2015.

Reprint requests to: Hugo Caˆmara-Costa, PhD, INSERM U1178 (Secteur Jaune, porte 45, 1er e´tage), 16 ave Paul Vaillant Couturier, 94807 Villejuif, France. Tel: 33 01 45 59 52 48; E-mail: hugocamaracosta@ gmail.com This manuscript corresponds to an original study performed by the authors. Preliminary findings were presented at the 16th International Symposium on Paediatric Neuro-Oncology, Singapore, June 2014. This study was supported by the Brain Tumour Charity; the Children’s Cancer and Leukaemia Group, Piam Brown Charitable Fund Southampton; the German Ministry of Health and Education (BMBF 01GI9958/5); the European Union Seventh Framework Programme (FP7 2007-2013) under Int J Radiation Oncol Biol Phys, Vol. 92, No. 5, pp. 978 e 985, 2015 0360-3016/$ - see front matter 2015 Elsevier Inc. All rights reserved. http://dx.doi.org/10.1016/j.ijrobp.2015.04.023

project European Network for Cancer Research in Children and Adoles- cents (ENCCA) grant agreement no. 261743; the German Children’s Cancer Foundation (Deutsche Kinderkrebsstiftung), Fo¨rdergemeinschaft Kinderkrebszentrum Hamburg e.V.; the French Ministry of Health; the French National Cancer Institute; the Swedish Childhood Cancer Foun- dation; Wessex Medical Research; and Cancer Research UK. HC-C and AR are co-first authors. Conflict of interest: none. Acknowledgments d The authors thank the participating families, PNET4 committee, and all PNET4 investigators.