paediatrics Brussels 17

Intracranial ependymoma

Ependymoma – international data / „infants“

Author, year

Pat.

RT

Survival

Grill et al., 2001

73 Chx only / RT at PD

4 y PFS : 26%/ 4 y. OS : 59% (23% without RT)

Grundy et al., 2007

89 Chx. only RT at PD

M0 EFS OS 3 y 47.6 79.3% 5 y 41.8% 63.4%

Fouladi et al., 2009

21 Planned RT

5 y PFS : 33% 5 y. OS : 62%

< 18 mon : 48Gy 18-30 mon. :51 Gy > 30 mon. : 54 Gy

Massimino et al.,

41 Chx. only / RT at PD

5 y PFS : 26%/ 5 y. OS : 37%

Merchant et al., 2009

78 RT only

5 y EFS : 68.6%/ OS : 80.4%

Grundy et al., 2010

11 Chx. only / RT at PD

1 y PFS : 1/11/ 1 y. OS : 9.1%

Timmermann et al., 2004 HIT 88-89/91

34 RT : 21

3 year PFS : 23.3% 3 year OS RT : 66.7%/ no RT : 38.5%

No RT : 13

HIT 2000

51 R0 : 61 R+ : 25

5 year PFS R0 : 84.3 / R+ : 63.5%