2017 Section 7 Green Book

No significant difference a between A and B A B A B 1,2,3,4,5 5.6 na 62.2 na 1,2,3,4,5 na na 37.5 na

Wang (United States) (27) 49 37 na na s na na na 9 na 40.8 na Raffaelli (Italy) (28) 124 62 A = 42.7 B = 43.2 A = 24:100 B = 13:49 A = 12.9 B = 12.1 na A = 51.6 B = 46.8 1,2,3,5 9.6 1.5 35.5 9.7 Barczynski (Poland) (29) 358 282 na A = 75:283 B = 60:222 na A = 13.1 B = 12.8 A = 37.7 B = 35.1 1,2,4,5 6.7 na na na

Bardet (France) (19) 36 161 na na na na na na na na 23.5 na Perrino (Italy) (20) 92 159 na na na na na na na na 33–52 na Costa (Italy) (21) 126 118 A = 46 B = 52 A = 26:100 B = 24:94 A = 17 B = 15 na A = 45.2 B = 40.7 2,4,5 na na 46.8 5.1 Zuniga 1,2,3 na na 82.4 na

1,2,3,4 na na 37.0 na

1,2,4,5 8.8 1.7 33.3 na

2,3,4,5 6.8 0.35 49.0 0.9

1,2,5 5 0 54.9 4.9

1,2,3,5 6.0 0.0 61.5 9.2

Incidence of

central LNM (%)

No. of central LNs excised

Table 1. Summary and Comparison of Baseline Characteristics Between Total Thyroidectomy + Prophylactic Central Neck Dissection (Group A) and Total Thyroidectomy Alone (Group B) No. of patients First author (country) A B Mean age at operation (years) Sex ratio (male:female) Mean tumor size (mm) ETE (%) Multifocality (%) Roh (Korea) (17) 40 73 A = na B = 48.5 A = na B = 9:64 A = na B = 22 A = na B = 30.1 A = na B = 15.1 Choi (Korea) (18) 48 53 A = 52 B = 48 A = 6:42 B = 11:42 A = 6.8 B = 7.3 A = 45.8 B = 58.5 A = 31.3 B = 22.6 (Columbia) (22) 136 130 A = 42.9 B = 41.5 A = 10:126 B = 13:117 na A = 44.8 B = 27.3 A = 38.2 B = 13.1 Moo (United States) (23) 45 36 A = 45.7 B = 49.2 A = 10:35 B = 4:32 A = 14 B = 20 A = 24.4 B = 36.1 A = 55.6 B = 63.9 Hughes (United States) (24) 78 65 A = 46.8 B = 41.2 A = 17:61 B = 16:49 A = 19 B = 20 A = 41.0 B = 16.9 A = 33.3 B = 33.8 Popadich (Australia, United States, and United Kingdom) (25) 259 347 A = 44 B = 48 A = 52:207 B = 81:266 A = 23 B = 22 A = 27.8 B = 24.2 A = 48.3 B = 42.7 So (Korea) (26) 119 113 A = 49.2 B = 49.8 A = 21:98 B = 16:97 A = 6.6 B = 6.2 A = 51.3 B = 51.3 A = 37.8 B = 23.9 Lang (China) (7) 82 103 A = 52.0 B = 50.0 A = 18:64 B = 22:81 A = 15 B = 10 A = 26.8 B = 14.6 A = 36.6 B = 27.2

a Matching: 1 = age; 2 = sex ratio; 3 = tumor size; 4 = extrathyroidal extension; 5 = tumor multifocality. s, significantly different ( p < 0.05) between groups A and B; ns, not significantly different between groups A and B; na, not available or specified; LN, lymph node; LNM, lymph node metastasis; ETE, extrathyroidal extension.

82