2017 Section 7 Green Book

S URGICAL MANAGEMENT OF OROPHARYNGEAL SCC

Intermediate 1.818 0.962–3.438 .0659 N/A N/A N/A N/A N/A N/A N/A N/A

Intermediate 2.322 1.397–3.861 .0012 N/A N/A N/A N/A N/A N/A N/A N/A

High 4.284 2.590–7.086 < .0001 275 N/A N/A N/A N/A N/A N/A N/A N/A Sex Female Ref Ref Ref

Yes 2.364 1.582–3.532 < .0001 286 2.396 1.432–4.010 .0009 111 1.921 0.985–3.744 .0553 169 HPV Positive Ref Negative 3.393 2.255–5.106 < .0001 289 N/A N/A N/A N/A N/A N/A N/A N/A Marital status Married Ref Ref Ref

Single/divorced/widowed 1.625 1.064–2.481 .0247 275 1.671 0.963–2.898 .0680 104 1.203 0.595–2.433 .6067 164 Mucosal margins Free of carcinoma Ref Ref Ref Positive 1.591 1.005–2.517 .0473 293 1.317 0.727–2.387 .3640 116 1.775 0.828–3.806 .1401 170 N classification N0/N1 Ref Ref Ref N2/N3 1.059 0.701–1.600 .7849 294 1.385 0.836–2.294 .2064 117 1.057 0.508–2.200 .8817 171 p16 status Positive Ref Negative 2.983 1.999–4.453 < .0001 288 N/A N/A N/A N/A N/A N/A N/A N/A Perineural invasion No Ref Ref Ref

High 4.801 2.831–8.141 < .0001 276 N/A N/A N/A N/A N/A N/A N/A N/A p16 risk group Low Ref

Other 2.417 1.233–4.739 .0102 2.836 1.323–6.080 .0074 0.561 0.072–4.403 .5828 Tonsil 0.963 0.605–1.533 .8739 295 1.798 0.987–3.274 .0550 117 0.584 0.279–1.221 .1529 171 Race White Ref African American/black 2.556 1.238–5.278 .0112 293 N/A N/A N/A N/A N/A N/A N/A N/A HPV risk group Low Ref

Male 1.223 0.743–2.013 .4292 296 0.949 0.507–1.776 .8691 117 1.268 0.553–2.909 .5752 172

Age, y 1.027 1.006–1.05 .0129 295 1.023 0.997–1.050 .0871 117 1.011 0.974–1.050 .5602 171 Approach Transoral Ref Ref Ref

Open 2.732 1.822–4.096 < .0001 296 1.449 0.865–2.426 .1589 117 3.899 1.964–7.742 .0001 172 Extranodal extension No Ref Ref Ref

Yes 2.453 1.653–3.642 < .0001 291 1.806 1.102–2.958 .0190 116 1.884 0.920–3.858 .0831 168 Primary site BOT Ref Ref Ref

No. of

patients

Variables HR 95% CI p value patients HR 95% CI p value patients HR 95% CI p value

Overall HPV negative HPV positive No. of No. of

TABLE 2. Univariate analysis of outcome predictors.

HEAD & NECK—DOI 10.1002/HED APRIL 2016

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