2017 Section 7 Green Book

TABLE I. Subject Characteristics.

Hypopharynx Cases (N 5 67)

Larynx Cases (N 5 473)

NOS Cases (N 5 247)

Oral Cavity Cases (N 5 192)

Oropharynx Cases (N 5 361)

Controls (N 5 1,378)

All Cases (N 5 1,340)

Variable

P Value*

Age (years)

< 0.0001

20–49

156 (11%)

254 (19%)

9 (13%)

64 (14%)

58 (23%)

37 (19%)

86 (24%)

50–54 55–59

161 (12%) 207 (15%)

210 (16%) 222 (17%)

16 (24%) 13 (19%)

50 (11%) 71 (15%)

40 (16%) 38 (15%)

20 (10%) 31 (16%)

84 (23%) 69 (19%)

60–64

205 (15%)

229 (17%)

10 (15%)

95 (20%)

41 (17%)

30 (16%)

53 (15%)

65–69 70–74

247 (18%) 231 (17%)

178 (13%) 152 (11%)

7 (10%)

81 (17%) 73 (15%)

30 (12%)

25 (13%) 29 (15%)

35 (10%)

3 (4%)

22 (9%)

25 (7%)

75–80

171 (12%)

95 (7%)

9 (13%)

39 (8%)

18 (7%)

20 (10%)

9 (2%)

Sex

0.0001

Male

960 (70%) 1,021 (76%)

56 (84%)

372 (79%) 171 (69%) 123 (64%) 299 (83%)

Female

418 (30%)

319 (24%)

11 (16%)

101 (21%)

76 (31%)

69 (36%)

62 (17%)

Race

< 0.0001

White

1,114 (81%)

989 (74%)

39 (58%)

345 (73%) 188 (76%) 140 (73%) 277 (77%)

Black

264 (19%)

351 (26%)

28 (42%)

128 (27%)

59 (24%)

52 (27%)

84 (23%)

Years Smoked Cigarettes

< 0.0001

Never smoker

525 (38%)

173 (13%)

5 (8%)

19 (4%)

57 (23%)

21 (11%)

71 (20%)

1–19

293 (21%)

118 (9%)

3 (5%)

26 (6%)

30 (12%)

12 (6%)

47 (13%)

20–39 40–49

334 (24%) 142 (10%)

499 (38%) 344 (26%)

26 (41%) 19 (30%)

180 (38%) 150 (32%)

68 (28%) 65 (27%)

79 (42%) 146 (41%)

47 (25%)

63 (18%)

50 1

78 (6%)

194 (15%)

10 (16%)

97 (21%)

25 (10%)

31 (16%)

31 (9%)

Lifetime Alcohol Consumption (mL)

< 0.0001

Never had alcohol

296 (22%)

125 (10%)

1 (2%)

45 (10%)

27 (12%)

23 (13%)

29 (9%)

< 11,232

161 (12%)

58 (5%)

3 (5%)

21 (5%)

15 (7%)

6 (3%)

13 (4%)

11,232- < 204,469 204,469- < 927,946

406 (31%) 321 (24%)

234 (19%) 319 (26%)

3 (5%)

77 (18%)

46 (20%) 53 (23%)

23 (13%) 42 (23%)

85 (25%) 90 (27%)

12 (20%)

122 (28%)

927,946 1

144 (11%)

497 (40%)

40 (68%)

169 (39%)

85 (38%)

86 (48%) 117 (35%)

Body Mass Index

< 0.0001

Underweight ( < 18.5) Normal (18.5- < 25.0) Overweight (25.0- < 30.0)

30 (2%)

100 (7%)

14 (21%)

25 (5%)

20 (8%)

20 (10%)

21 (6%)

405 (29%)

482 (36%)

26 (39%)

161 (34%)

93 (38%)

88 (46%) 114 (32%)

551 (40%) 392 (28%)

434 (32%) 324 (24%)

19 (28%)

159 (34%) 128 (27%)

71 (29%) 63 (26%)

55 (29%) 130 (36%)

Obese (30.0 1 )

8 (12%)

29 (15%)

96 (27%)

Education

< 0.0001

Less than high school

217 (16%) 490 (36%)

458 (34%) 492 (37%)

32 (48%) 18 (27%)

197 (42%) 173 (37%)

64 (26%) 89 (36%)

67 (35%)

98 (27%)

High school/vocational/tech

73 (38%) 139 (39%)

At least some college

671 (49%)

390 (29%)

17 (25%)

103 (22%)

94 (38%)

52 (27%) 124 (34%)

Ever had frequent heartburn

0.8

No

1,007 (76%)

989 (77%)

43 (69%)

344 (75%) 194 (81%) 145 (81%) 263 (74%)

Yes

315 (24%)

303 (23%)

19 (31%)

112 (25%)

47 (20%)

34 (19%)

91 (26%)

Ever diagnosed with GERD

0.1

No

994 (77%) 1,008 (79%)

53 (84%)

329 (73%) 200 (84%) 147 (83%) 279 (80%)

Yes

303 (23%)

266 (21%)

10 (16%)

120 (27%)

37 (16%)

31 (17%)

68 (20%)

*Chi-square comparisons between controls and overall cases. NOS 5 Not otherwise specified, GERD 5 gastroesophageal reflux disease

We also found no association between self-reported medical diagnosis of GERD and the odds of overall HNSCC (Table II). Most ORs were again in an inverse direction, but laryngeal cases had a slightly greater odds of having been diagnosed with GERD compared to controls. In analyses of combined laryngeal and pharyngeal cases, among those who were neither heavy smokers nor

heavy drinkers we detected no association between GERD and the development of laryngopharyngeal cancer for either self-reported history of GERD symptoms or medical diagnosis of GERD (Table III). Likewise, no associations between GERD and laryngopharyngeal cancer were detected among subjects who were heavy smokers and/or heavy drinkers (Table III).

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