2017 Section 7 Green Book

Ito et al 20 2010 53 Mean, 59.4 68 Various HNSCC, stage III/IV; intra-arterial CRT PET Visual 8-12 wk Biopsy or clinical and imaging follow-up 9 mo NR 12.5 Kim et al 21 2007 97 Median, 57 (range, 17-84) 88 Various HNSCC; M0 only; RT 6 chemo PET Semiquantitative (cutoff: 3) 1 mo Biopsy or clinical follow-up 6 mo Median, 20 mo (range, 6-30 mo) 12 Kishino et al 22 2012 28 Range, 40-83 89 Various HNSCC; CCRT PET Visual Median, 5 wk (range, 3-11 wk) Biopsy/neck dissection or clinical and imaging follow-up Median, 39 mo (range, 12-65 mo) 11 Kitagawa et al 23 2003 23 Mean, 63.8 (range, 47-85) 78 Oral HNSCC; intra-arterial CRT PET Semiquantitative Mean, 38 d Histopathology or clinical follow- up 12 mo NR 13 Kubota et al 24 2004 36 Range, 19-82 86 Various HNSCC; intra-arterial CRT; symptomatic at recurrence PET Visual Median, 4 mo Histopathology or clinical follow- up 12 mo NR 11.5 Li et al 25 2001 43 NR NR Various HNSCC; RT 6 chemo 6 sx; symptomatic at recurrence PET Visual Mean, 11 mo (range, 4-36 mo) Biopsy or clinical follow-up 6 mo NR 11 11 Moeller et al 27 2009 98 Mean, 58 (range, 36-79) 85 OPX/HPX/LX HNSCC; stage III/IV; RT 6 chemo PET/CT Semiquantitative (cutoff: local 6.5, nodal 2.8) 5-12 wk Histopathology or clinical and imaging follow-up 6 mo Range, 37-122 wk 11.5 Mori et al 28 2011 65 Mean, 65 (range, 36-85) 88 Various HNSCC, CCRT PET Semiquantitative 4-6 wk Local: Hispathology Nodal: FNAC NR 12.5 disease only McCollum et al 26 2004 40 Median, 54 (range, 29-78) 78 Various HNSCC; stage III/IV; induction chemo 1 CRT PET Visual 4-12 wk Histopathology Median, 20.5 mo (range, 9.7-30 mo)

Nam et al 29 2005 24 Median, 59 (range, 17-78) 96 Various HNSCC; M0 only; RT PET Semiquantitative (cutoff: 3) 4-6 wk Histopathology or clinical follow-up 6 mo Median, 12 mo (range, 7-16 mo) 10 PET/CT NR 2-5 mo Histopathology/neck dissection or clinical follow-up 5 mo Median, 18.1 mo 11 PET/CT Visual Mean, 6.5 mo (range, 2.8- 35.6 mo) Biopsy or clinical and imaging follow-up 12 mo NR 11.5 Porceddu et al 32 2005 39 Median, 55 (range, 37-89) 74 Various HNSCC; stage III/IV; RT 6 chemo; symptomatic at recurrence PET NR Median, 12 wk (range, 8-32 wk) Histopathology or clinical follow- up 12 mo Median, 34 mo (range, 16-86 mo) 10 Rege et al 33 1994 15 Range, 23-80 80 Various HNSCC; RT 6 chemo PET Visual 2.5-192 wk HIstopathology OR clinical follow-up NR 12 only PET Visual 1 mo Planned neck dissection NR 12 Nayak et al 30 2007 43 NR NR Various HNSCC; stage IV; M0 only; CRT; neck Ng et al 31 2011 79 Mean, 52.4 (range, 33-74) 89 OPX/HPX HNSCC; stage II/III/IV; CCRT; suspected recurrence

Brkovich et al 11 2006 19 Mean, 58.6 (range, 47-74) 100 Various HNSCC; RT/CRT; primary site Ceulemans et al 12 2001 40 Range, 34-80 83 Various HNSCC; RT 6 chemo PET Visual 4 mo Biopsy or clinical follow-up . 4 mo Median, 26 mo (range, 7-50 mo) 12 NR 11 confirmed disease free; neck disease only PET NR Mean, 8.95 wk (range, 7-12 wk) Planned neck dissection Mean, 11.5 mo (range, 8-24 mo) 12.5

Conessa et al 14 2004 42 Mean, 60 (range, 43-78) 88 Various HNSCC, stage II, III, IV; RT postchemo/ sx PET Visual 3-6 mo Biopsy or clinical and imaging follow-up Mean, 17 mo (range, 8-36 mo) 11 Fakhry et al 15 2006 61 Mean, 57.5 (range, 41-82) 85 Various HNSCC; Sx 1 RT/CRT/RT/CCRT PET Semiquantitative Mean, 3.5 mo (range, 2-5 mo) Biopsy or clinical follow-up . 6 mo Mean, 7.4 mo (range, 6-14 mo) 11.5 Goerres et al 16 2000 28 Range, 28-82 75 Various HNSCC; M0 only; RT 6 chemo 6 neck dissection PET NR Mean, 13 mo (range, 6-35 mo) Biopsy or clinical follow-up 6 mo NR 11.5

Rogers et al 34 2004 12 NR NR Various HNSCC; stage III/IV; RT; neck disease Sjovall et al 35 2014 82 Median, 62 (range, 34-89) 76 OPX/HPX/LX HNSCC; stage III/IV; M0 only; RT 6 chemo PET/CT Visual Mean, 44 d Endoscopy 6 biopsy or clinical follow-up 9 mo NR 11.5 Wang et al 36 2009 44 Median, 50 (range, 34-78) 95 Various HNSCC; induction chemo 1 CCRT PET Semiquantitative Median, 16 wk (range, 12-17 wk) Biopsy or clinical follow-up 12 mo NR 12.5 Yen et al 37 2006 39 Median, 51 (range, 15-79) 69 NPC; CCRT PET Semiquantitative 3 mo Histopathology or clinical and imaging follow-up 12 mo Mean, 24.2 mo (range, 11.1-40.6 mo) 11.5 Abbreviations: chemo, chemotherapy; CCRT, concurrent chemoradiotherapy; CRT, chemoradiotherapy; CT, computed tomography; FNAC, fine-needle aspiration cytology; HNSCC, head and neck squamous cell carcinoma; HPX, hypopharynx; LX, larynx; M0, no metastasis; OPX, oropharynx; QUADAS, Quality Assessment of Diagnostic Accuracy Studies; RT, radiotherapy; NPC, nasopharyngeal carcinoma; NR, not reported; PET, positron emission tomography; Sx, surgery.

Goerres et al 17 2004 26 Mean, 56 (range, 35-76) 96 Various HNSCC; stage III/IV; CCRT PET Visual Mean, 45 d (range, 40-59 d) Histopathology or clinical follow- Gupta et al 18 2010 57 Median, 54 (range, 33-65) 89 OPX/HPX/LX HNSCC; RT 6 chemo PET/CT Semiquantitative Median, 9 wk (range, 5-39 wk) Inohara et al 19 2009 48 Mean, 43 (range, 41-48) 85 OPX/HPX/LX HNSCC; M0 only; CRT; Asymptomatic at recurrence; neck disease only PET Visual 7 wk Histopathology or clinical follow- up 10 mo Median, 20 mo (range, 10-41 mo) 12.5 Local: biopsy or clinical follow-up 12 mo Nodal: FNAC 6 neck dissection Median, 36 mo (range, 7-45 mo) 12.5

Chaiken et al 13 1993 14 Range, 23-84 64 Various HNSCC; RT, some symptomatic at recurrence PET Semiquantitative 2-120 wk Pathology or clinical and imaging follow-up NR 10.5 up 6 mo

Scan Reference Standard Duration of Follow-up QUADAS

Time from Treatment to

Study Patients, n Age, y Male, % Patient Characteristics Scan Type Interpretation of Scan

Table 1. Characteristics of Studies

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