2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Implantable devices

Drug must be extremely potent, as totalmass dose to be loaded is small • E.g., etonogestrel implant .06mg/day

Chua, CROI 2017 Durham, CROI 2018 Hendrix,MTN 2017

Slide56of58FromHScott,MD,MPHatNewOrleans,LA,December4-7, 2019,RyanWhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Formulation PK profiles compared

Slide57of58FromHScott,MD,MPHatNewOrleans,LA,December4-7, 2019,RyanWhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Question-and-Answer Period

FromHScott,MD,MPH atNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.