2016 OMB Summer Meeting

AOAC OMB Meeting Book

196

 Developed LC/MS/MS methods for metabolite profiling for PK studies.  Supported stability programs with HPLC, LC/MS/MS, LC/UV/MS, and LC/RI/MS techniques.

Teva Pharmaceuticals USA (Mexico, MO) Senior Research Chemist, R&D Department

May 1995-June1997  Expertise in the structure elucidation of impurities and degradation products of drug substances (APIs) and drug products by LC/MS. Provided data for regulatory filing of 4 drug master (DMF) files.  Conducted preparative HPLC separation of impurities from active drug ingredients.  Characterized proteins and carbohydrates in natural products. Supported immediate and sustained release formulations. Pacific Northwest National Laboratory (Richland, WA) Post Doctoral Research Associate March 1994-May 1995 Bioanalytical research with characterization of proteins, DNA, RNA, and supramolecular complexes using ESI-MS, LC/MS and CE/MS techniques. Designed, constructed and characterized a novel space-focusing Time-of-Flight mass spectrometer. EDUCATION B. Sc. in Chemistry, Nanjing University, China, 1982 M. Sc. in Chemistry, Dalian Inst. of Chem. Phys., Chinese Academy of Sciences, 1985. Ph. D. in Chemistry, University of California, Irvine, 1991. Post-Doctoral Research, University of Pittsburgh and Pacific Northwest National Laboratories. PROFESSIONAL ORGANIZATIONS USP Expert Committee Member: Chemical Medicine Monographs 4 SELECTED PUBLICATION 1. Analytical Methods Development and Methods Validation for Solid Oral Dosage Forms, Q, Gao, D. Sanvordeker, and R. Vita, Chapter 3 of Generic Drug Product Development , 2004, Marcel Dekker, New York, ed. Leon Shargel and Isadore Kanfer. 2. HPLC-Quadrupole Ion Trap Mass Spectrometry Studies of Thermal Degradation of Beclomethasone Dipropioate, Q. Gao, A. K. Sharma, W. Walter , J. Am. Soc. Mass Spectro ., 9(1998)387. 3. Late-infantile Ceroid-lipofuscinosis: Lysine Methylation of Mitochondrial ATP Synthase Subunit c From Lysosomal Storage Bodies, Biochimica et Biophysica Acta , vol. 1361 (1997) 66, M. L. Katz, A. N. Siakotos, Q. Gao, B. Freiha, D. T. Chin. 4. Binding Specificity of Post-activated Neocarzinostatin Chromophore Drug-Bulged DNA Complex Studied Using Electrospray Ionization Mass Spectrometry, J. Mass Spectro. , 31 (1996) 31. 5. Characterization of Hydrogen-Bonded Aggregates in Chloroform by Electrospray Ionization Mass Spectrometry, J. Org. Chem . , 61 (1996) 2204.

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