Palliative care 2016

Systemic treatments prevents bone events

Reduce skeletal related events (SREs) Fracture, surgical intervention, need for radiotherapy, SCC - Increase bone mass / strength - No effect on pain

Porta- Sales et al, Pall Med 2016

Bisphosphonates - Oral - IV

•

RANK-L inhibitors - Denosumab sc 1 per month

•

Peddi et al, Canc Treat Rev 2013

Ra 223 - Phase 3 ALSYMPCA study, prostate cancer, n= 921 - Outcome 33% SRE vs. 38% - Time to first SRE 15,6 vs. 9,8 months

•

Sartor et al, Lancet Oncol 2014

66

15-sep-16