Palliative care 2016

Leucoencephalophaty after WBRT

67 year-old woman treated with PCI 30 Gy/15 frx for SCLC in 2006. SRS for isolated recurrence may 2008. Reduced memory in 2008. Progressive dementia thereafter (hospice 2010).

12 patients 5-36 mts. after WBRT • progressive dementia • ataxia • urinary incontinence • severe disability • 7 deaths

Sahgal et al. Prog Neurol Surg 2012; 25: 82 DeAngelis et al. Neurology 1989;39:789