Palliative care 2016

Some authors suggest

Morfine slow release 5mg po x2/d Uptitrate to 1-2,5 mg po/4h by the end of the first week Doses are uptitrated by 25% weekly until adequate symptom relief is achieved Other authors use sustained release morphine Starting dose 10 mg/d and titrated weekly to 20 or 30 mg/d without respiratory depression or significant side effects

è Compliance is highest with once daily dosing or patch/3 days