2017_SBRT_Course Book

Radiotherapy: WBRT- with integrated boost plus hippocampal-sparing

Study design

Endpoint Planning comparison

Dose PTV wb

Cases (lesions)

Main findings

/dose

PTV m(Gy)

Hsu 2010

Feasibility WBRT+SIB(VMAT) vs SRS

32.25 (63-70) 10(1-3)

Adequate WBRT and SRT dose distribution 60 Gy /10 f. to 1-3 mets synchron.with 30 Gy WBRT feasible For non deep BM 47.5 Gy /5f is feasible 50 Gy /10f to 1-5 meta feasible

Rodrigues 2011

Phase 1 WBRT+SIB

30 (35-60)

48(1-3)

Nichol 2016

Phase 2 WBRT+Volumetric Radiosurgery

20 (47.5)

60 (223)

Ferro 2017

Phase 1 WBRT+SIB(IMRT)

30 (35-50)

30(1-5)

• Treatment planning is possible • Long term results of neurocognitive decline are not available