2017_SBRT_Course Book

Blood brain barrier

Zytostatikum

Liquorpenetration

Nitrosoureas (ACNU,BCNU; CCNU, Fotemustine)

++

Procarbacin

++

Thiotepa

+

Dacarbacin Temozolomide

(+) ++ +/- ++ -/+ - ++ -/+ -/+

Cyclophosphamid, Ifosfamid

Cytosinarabinosid

Methotrexat 5-Fluorouracil

(++)

Anthracyclins Liposomal doxorubicine

VM26

Etoposid

Vincaalkaloids, Taxanes

-

Topotecan

++

Cisplatin, Carboplatin

-

Cytokines - ++ : Liquorconzentration 20-30% of the Serumconzentration + : Liquorconzentration 10% of the Serumconzentration – : Liquorconzentration <5% of the Serumconzentration There is a limited effect of Chemotherapy in brain metastases

B. Müller, M. Bamberg, P. Krauseneck, Maligne Gehirntumoren, 1995