2017_SBRT_Course Book

Re-irradiation tolerance and recovery

Full – partial recovery • Lung pneumonitis • Skin • Mucosa

Partial recovery

No recovery

• Plexus • Spinal cord • Bone • Mesenchymal • Small intestine

• Heart • Lung fibrosis • Heart

• Bladder • Kidney

Factors associated with recovery: • Initial biological dose in relationship to tolerance dose • Initial volume irradiated • Time interval between treatment courses

07.09.17 ESTRO SBRT 2017 - Matthias Guckenberger

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Re-irradiation tolerance and recovery

Full – partial recovery • Lung pneumonitis • Skin • Mucosa

Partial recovery • Plexus • Spinal cord • Bone • Mesenchymal • Small intestine

No recovery • Heart • Lung fibrosis • Heart

• Bladder • Kidney

• Acute toxicity • Relevant for palliative RT

• Late toxicity • Relevant for „ curative “ RT

Ø All organs, which are relevant for acute toxicity in the palliative setting, show relevant recovery

07.09.17 ESTRO SBRT 2017 - Matthias Guckenberger

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